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Nickel-Catalyzed Regio- and Enantioselective Hydroamination of Unactivated Alkenes Using Carbonyl Directing Groups

Changseok Lee, Hyung-Joon Kang, Huiyeong Seo and Sungwoo Hong*

*Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea, Email:

C. Lee, H.-J. Kang, H. Seo, S. Hong, J. Am. Chem. Soc., 2022, 144, 9091-9100.

DOI: 10.1021/jacs.2c02343

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A highly enantio- and regioselective Ni-catalyzed hydroamination of readily available unactivated alkenes bearing weakly coordinating native amides or esters provides β- or γ-amino acid derivatives and 1,2- or 1,3-diamines for both terminal and internal unactivated alkenes and a broad amine coupling partner scope. The mild reaction is well suited for late-stage functionalization.

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Key Words

β-amino amides, dimethoxymethylsilane

ID: J48-Y2022