Nickel-Catalyzed Regio- and Enantioselective Hydroamination of Unactivated Alkenes Using Carbonyl Directing Groups
Changseok Lee, Hyung-Joon Kang, Huiyeong Seo and Sungwoo Hong*
*Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea, Email: hongorgkaist.ac.kr
C. Lee, H.-J. Kang, H. Seo, S. Hong, J. Am. Chem. Soc., 2022, 144, 9091-9100.
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A highly enantio- and regioselective Ni-catalyzed hydroamination of readily available unactivated alkenes bearing weakly coordinating native amides or esters provides β- or γ-amino acid derivatives and 1,2- or 1,3-diamines for both terminal and internal unactivated alkenes and a broad amine coupling partner scope. The mild reaction is well suited for late-stage functionalization.
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β-amino amides, dimethoxymethylsilane