KOtBu-Mediated Reductive Cyanation of Tertiary Amides for Synthesis of α-Aminonitriles
Liwen Liu, Yu Liu, Xue Shen, Xiao Zhang, Shengqi Deng and Yang Chen*
*Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China, Email: chenyang1cdu.edu.cn
L . Liu, Y. Liu, X. Shen, X. Zhang, S. Deng, Y. Chen, J. Org. Chem., 2022, 87, 6321-6329.
see article for more reactions
A simple, mild, catalyst-free, and efficacious KOtBu-mediated reductive cyanation reaction of tertiary amides provides a series of α-aminonitriles in good yields under hydrosilylation conditions with good functional group tolerance. The reaction works well with readily available amide substrates, cheap KOtBu, and a commercially available hydrosilane (EtO)3SiH and the workup is convenient.
see article for more examples