Efficient Synthesis of N-Carbamoylpropargylamines from α-Amido Sulfones Using Dimethylalkynylaluminum Reagents
Ji-Hoon Lee, Sang-Hyeup Lee*
*Department of Chemistry, Daegu Catholic University,
Hayang-Ro 13-13, Gyeongsan, Gyeongbuk 38430, Korea, Email: leeshh
cu.ac.kr
J.-H. Lee, S.-H. Lee, Synthesis, 2022, 54, 2233-2241.
DOI: 10.1055/s-0041-1737763
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Abstract
The addition of dimethylalkynylaluminum reagents derived from terminal alkynes and trimethylaluminum to various N-activated α-amido sulfones provides the corresponding propargylamines in good yields. The use of stable, N-activated α-amido sulfone avoids the preparation and isolation of relatively unstable N-activated imines.
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Key Words
ethylalkynylaluminum reagents, nucleophilic addition, propargylamines, N-activated α-amido sulfones, alkynylamines
ID: J66-Y2022
