Organic Chemistry Portal



Access to 4-Trifluoromethyl Quinolines via Cu-Catalyzed Annulation Reaction of Ketone Oxime Acetates with ortho-Trifluoroacetyl Anilines under Redox-Neutral Conditions

Zhen-Hua Wang*, Li-Wen Shen, Ping Yang, Yong You, Jian-Qiang Zhao and Wei-Cheng Yuan*

*Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China, Email:,

Z.-H. Wang, L.-W. Shen, P. Yang, Y. You, J.-Q. Zhao, W.-C. Yuan, J. Org. Chem., 2022, 87, 5804-5816.

DOI: 10.1021/acs.joc.2c00128

see article for more reactions


An efficient Cu-catalyzed annulation reaction of ketone oxime acetates with ortho-trifluoroacetyl anilines provides 4-trifluoromethyl quinolines in very good yields under redox-neutral conditions.

see article for more examples

proposed mechanism

Key Words


ID: J42-Y2022