Access to 4-Trifluoromethyl Quinolines via Cu-Catalyzed Annulation Reaction of Ketone Oxime Acetates with ortho-Trifluoroacetyl Anilines under Redox-Neutral Conditions
Zhen-Hua Wang*, Li-Wen Shen, Ping Yang, Yong You, Jian-Qiang Zhao and Wei-Cheng Yuan*
*Innovation Research Center of Chiral Drugs, Institute for
Advanced Study, Chengdu University, Chengdu 610106, China, Email: wangzhenhua
cdu.edu.cn,
yuanwccioc.ac.cn
Z.-H. Wang, L.-W. Shen, P. Yang, Y. You, J.-Q. Zhao, W.-C. Yuan, J. Org. Chem., 2022, 87, 5804-5816.
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Abstract
An efficient Cu-catalyzed annulation reaction of ketone oxime acetates with ortho-trifluoroacetyl anilines provides 4-trifluoromethyl quinolines in very good yields under redox-neutral conditions.
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proposed mechanism
Key Words
ID: J42-Y2022
