Organic Chemistry Portal



Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Oxygen-Substituted Allylboronates with Aryl/Vinyl (Pseudo)Halides

Jie Li, Xinhui Zhang, Yisen Yao, Yapei Gao, Wen Yang* and Wanxiang Zhao*

*College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, PR China, Email:,

J. Li, X. Zhang, Y. Yao, Y. Gao, W. Yang, W. Zhao, J. Org. Chem., 2022, 87, 6951-6959.

DOI: 10.1021/acs.joc.2c00634

see article for more reactions


An efficient palladium-catalyzed Suzuki-Miyaura reaction of oxygen atom-substituted allylboronates with aryl/vinyl bromides, iodides, and triflates provides various allylic siloxanes with high efficiency and excellent regioselectivity. This alternative approach for the synthesis of allylic alcohols offers broad substrate scope, excellent functional group tolerance, and gram-scale preparation.

see article for more examples

Key Words

Suzuki coupling, alcohols, allylation

ID: J42-Y2022