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Dichlorination of β-Keto Esters and 1,3-Diketones Mediated by Oxone/Aluminum Trichloride Mixture in Aqueous Medium

Vasileios Giannopoulos, Nikolaos Katsoulakis, Ioulia Smonou*

*Department of Chemistry, University of Crete, 71003 Voutes, Heraklion, Greece, Email: smonouuoc.gr

V. Giannopoulos, N. Katsoulakis, I. Smonou, Synthesis, 2022, 54, 2457-2463.

DOI: 10.1055/s-0041-1737412


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Abstract

The use of Oxone/aluminum trichloride mixture enables an α,α-dichlorination of β-keto esters and 1,3-diketones in aqueous medium. The dichlorinated compounds have been produced in one step, high yields, and short reaction times.

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Key Words

Oxone, aluminum trichloride, dichlorination, chlorination of ketones, chlorination of esters, β-dicarbonyl compounds


ID: J66-Y2022