Scalable Electrocatalytic Intermolecular Acylcyanation and Aminocyanation of Alkenes

Xianqiang Kong*, Xiaohui Chen*, Yiyi Chen and Zhong-Yan Cao*

*Changzhou Institute of Technology, Changzhou 213032; Henan University, Kaifeng 475004, China, Email: kongxqczu.cn, chenxhczu.cn, zycaohenu.edu.cn

X. Kong, X. Chen, Y. Chen, Z.-Y. Cao, J. Org. Chem., 2022, 87, 7013-7021.

DOI: 10.1021/acs.joc.1c03134

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Abstract

The use of an electrophilic cyanation source enables electrocatalytic three-component acylcyanations and aminocyanations of a broad range of simple alkenes. The reaction offers high functional group tolerance and can easily be scaled up.

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proposed mechanism

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Key Words

cyanation, acylation, multicomponent reactions, electrochemistry

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ID: J42-Y2022