Iridium-Catalyzed Acceptorless Dehydrogenative Coupling of 2-Aminoarylmethanols with Amides or Nitriles to Synthesize Quinazolines
Hongling Shui, Yuhong Zhong, Lu Ouyang, Nianhua Luo*, Renshi Luo*
*School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, Jiangxi Province, P. R. of China, Email: luoxiaoge102163.com, luorenshi2010163.com
H. Shui, Y. Zhong, L. Ouyang, N. Luo, R. Luo, Synthesis, 2022, 54, 2876-2884.
DOI: 10.1055/a-1755-4700
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Abstract
An efficient iridium-catalyzed acceptorless dehydrogenative coupling (ADC) reaction of 2-aminoarylmethanols and amides or nitriles provides various quinazolines in excellent yields. This method offers high atom-economy, mild reaction conditions, and simple operation.
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Key Words
dehydrogenative coupling, quinazolines, iridium-catalyzed
ID: J66-Y2022