Organic Chemistry Portal

Abstracts

Search:

Iridium-Catalyzed Acceptorless Dehydrogenative Coupling of 2-Aminoarylmethanols with Amides or Nitriles to Synthesize Quinazolines

Hongling Shui, Yuhong Zhong, Lu Ouyang, Nianhua Luo*, Renshi Luo*

*School of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, Jiangxi Province, P. R. of China, Email: luoxiaoge102163.com, luorenshi2010163.com

H. Shui, Y. Zhong, L. Ouyang, N. Luo, R. Luo, Synthesis, 2022, 54, 2876-2884.

DOI: 10.1055/a-1755-4700



see article for more reactions

Abstract

An efficient iridium-catalyzed acceptorless dehydrogenative coupling (ADC) reaction of  2-aminoarylmethanols and amides or nitriles provides various quinazolines in excellent yields. This method offers high atom-economy, mild reaction conditions, and simple operation.

see article for more examples



Key Words

dehydrogenative coupling, quinazolines, iridium-catalyzed


ID: J66-Y2022