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Rapid Access to Aliphatic Sulfonamides

Mingjun Zhang, Mo Yu, Ziwen Wang*, Yuxiu Liu and Qingmin Wang*

*College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, China, Email: wangziwen2725163.com, wangqmnankai.edu.cn

M. Zhang, M. Yu, Z. Wang, Y. Liu, Q. Wang, Org. Lett., 2022, 24, 3932-3937.

DOI: 10.1021/acs.orglett.2c01236


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Abstract

A mild, rapid, straightforward visible-light-mediated sulfonamide ethylation of easily available redox active esters or alkyl iodides with vinylsulfonamides provides a diverse array of compounds with C(sp3)-sulfonamide skeletons. This method offers a broad substrate scope and has  and potential utility for late-stage functionalization of natural products and synthetic medicines.

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proposed mechanism



Key Words

sulfonamides, photochemistry, organocatalysis, Hantzsch ester


ID: J54-Y2022