Asymmetric Hydrophosphonylation of α,β-Unsaturated Ketones Catalyzed by Rare-Earth Metal Complexes Bearing Trost Ligands

Huifang Song, Yuli Sun, Chengrong Lu* and Bei Zhao*

*College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China, Email: luchengrongsuda.edu.cn, zhaobeisuda.edu.cn

H. Song, Y. Sun, C. Lu, B. Zhao, J. Org. Chem., 2022, 87, 7749-7762.

DOI: 10.1021/acs.joc.2c00342

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Abstract

Chiral dinuclear rare-earth metal complexes stabilized by Trost ligands displayed high reactivity in the asymmetric hydrophosphonylation of α,β-unsaturated ketones in the presence of (1S,2S)-1,2-cyclohexanediamine as additive. Various hydrophosphonylation products with excellent yields and very high ee values were obtained.

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Gd₂(ligand)₂

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Key Words

Phosphonates

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ID: J42-Y2022