Palladium-Catalyzed Three-Component Selective Aminoallylation of Diazo Compounds
Pengcheng Ou, Lei Zhu, Yinghua Yu, Liyao Ma and Xueliang Huang*
*College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan 410081, China, Email:
huangxl
hunnu.edu.cn
P. Ou, L. Zhu, Y. Yu, L. Ma, X. Huang, Org. Lett., 2022, 24, 4109-4113.
DOI: 10.1021/acs.orglett.2c01399
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Abstract
A Xantphos-containing dinuclear palladium complex catalyzes a geminal aminoallylation of diazocarbonyl compounds to provide a range of quaternary α-amino esters. Direct N-H insertion, allylic alkylation of amino nucleophiles, and diene formation were not observed under standard conditions.
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proposed mechanism
Key Words
α-amino esters (amination, alkylation), multicomponent reactions
ID: J54-Y2022
