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Transition Metal-Free Iodine-Catalyzed Denitrative C-S Cross-Coupling: An Atypical Route to Access Thiochromane Derivatives

Anuradha Nandy and Govindasamy Sekar*

*Department of Chemistry, Indian Institute of Technology Madras, Chennai600 036, Tamil Nadu, India, Email: gsekariitm.ac.in

A. Nandy, G. Sekar, J. Org. Chem., 2022, 87, 7536-7546.

DOI: 10.1021/acs.joc.2c00425


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Abstract

An iodine-catalyzed denitrative C-S cross-coupling reaction provides thiochromanones from 2′-nitrochalcones and xanthate. The strategy was extended for a three-component synthesis of thiochromenes via intermolecular C-S cross-coupling followed by aldol reaction.

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proposed mechanism



Key Words

thiochromanones


ID: J42-Y2022