Rh-Catalyzed Highly Enantioselective Hydrogenation of Functionalized Olefins with Chiral Ferrocenylphosphine-Spiro Phosphonamidite Ligands
Yirui Chen, Xiao Yi, Yuqi Cheng, An Huang, Zehui Yang, Xianghua Zhao, Fei Ling* and Weihui Zhong*
*College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, People’s Republic of China, Email: Lingfeizjut.edu.cn, weihuizhongzjut.edu.cn
Y. Chen, X. Yi, Y. Cheng, A. Huang, Z. Yang, X. Zhao, F. Ling, W. Zhong, J. Org. Chem., 2022, 87, 7864-7874.
DOI: 10.1021/acs.joc.2c00532
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Abstract
The use of a highly rigid chiral ferrocenylphosphine-spiro phosphonamidite ligand enables a highly efficient Rh-catalyzed hydrogenation of a wide range of α-dehydroamino acid esters and α-enamides with excellent enantiocontrol.
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Key Words
reduction of enamines, 1,4-reduction of α,β-unsaturated compounds, hydrogen
ID: J42-Y2022