Highly Diastereoselective Synthesis of γ-Lactams Enabled by Photoinduced Deaminative [3 + 2] Annulation Reaction
Chengcheng Shi, Lin Guo, Han Gao, Mengqi Luo, Chao Yang* and Wujiong Xia*
*State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology, Shenzhen, Guangdong 518055, China,
Email: xyyang
hit.edu.cn, xiawjhit.edu.cn
C. Shi, L. Guo, H. Gao, M. Luo, C. Yang, W. Xia, Org. Lett., 2022, 24, 4365-4370.
DOI: 10.1021/acs.orglett.2c01565
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Abstract
A photoinitiated deaminative [3 + 2] annulation reaction of N-aminopyridinium salts with alkenes provides functionalized γ-lactams. This transformation shows good functional group tolerance as well as excellent diastereoselectivity.
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proposed mechanism
Key Words
γ-lactams, photochemistry
ID: J54-Y2022
