Palladium-Catalyzed Asymmetric Sequential Hydroamination of 1,3-Enynes: Enantioselective Syntheses of Chiral Imidazolidinones
Qiuyu Li, Xinxin Fang, Rui Pan, Hequan Yao* and Aijun Lin*
*Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China,
Email: hyao
cpu.edu.cn, ajlincpu.edu.cn
Q. Li, X. Fang, R. Pan, H. Yao, A. Lin, J. Am. Chem. Soc., 2022, 144, 11364-11376.
DOI: 10.1021/jacs.2c03620
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Abstract
Pd-catalyzed sequential hydroaminations of readily available 1,3-enynes provide a broad scope of imidazolidinones, thiadiazolidines, and imidazolidines. Asymmetric sequential hydroamination generates a series of synthetically valuable, enantioenriched imidazolidinones.
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Key Words
ID: J48-Y2022
