Palladium-Catalyzed Regioselective [5 + 1] Annulation of Vinyl Aziridines/Epoxides with ClCF2COONa
Dandan Zuo, Tao Zhang, Jingjing Zhao*, Wen Luo*, Chaojie Wang and Pan Li*
*Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, P. R. China, Email: zhaojingjinghenu.edu.cn, luowen83163.com, panlihenu.edu.cn
D. Zuo, T. Zhang, J. Zhao, W. Luo, C. Wang, P. Li, Org. Lett., 2022, 24, 4630-4634.
DOI: 10.1021/acs.orglett.2c01739
see article for more reactions
Abstract
In palladium-catalyzed regioselective [5 + 1] annulation reactions of vinyl aziridines/epoxides with ClCF2COONa, vinyl aziridines/epoxides act as heteroatom-containing five-atom synthons, and commercially available and cheap ClCF2COONa is the carbonyl source. This protocol efficiently provides δ-lactams and δ-lactones in good yields.
see article for more examples
proposed mechanism
T. Zhang, S. Wang, D. Zuo, J. Zhao, W. Luo, C. Wang, P. Li, J. Org. Chem., 2022, 87, 10372-10376.
Key Words
ID: J54-Y2022