Asymmetric Transfer Hydrogenative Amination of Benzylic Ketones Catalyzed by Cp*Ir(III) Complexes Bearing a Chiral N-(2-Picolyl)sulfonamidato Ligand
Takuma Kawada, Kenya Yabushita, Toshihisa Yasuda, Takeshi Ohta, Takaaki Yajima, Kouichi Tanaka, Noriyuki Utsumi, Masahito Watanabe, Kunihiko Murata, Yoshihito Kayaki, Shigeki Kuwata* and Takeaki Katayama
*School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1-E4-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan, Email: skuwatafc.ritsumei.ac.jp
T. Kawada, K. Yabushita, T. Yasuda, T. Ohta, T. Yajima, K. Tanaka, N. Utsumi, M. Watanabe, K. Murata, Y. Kayaki, S. Kuwata, T. Katayama, J. Org. Chem., 2022, 87, 8458-8468.
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Cp*Ir complexes bearing a chiral N-(2-picolyl)sulfonamidato catalyze a convenient asymmetric reductive amination of benzylic ketones using readily available β-amino alcohols as chiral aminating agents. The amino alcohol-derived chiral auxiliary was easily removed by mild periodic oxidants, leading to optically active primary β-arylamines without erosion of the optical purity.
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