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Nickel-Catalyzed Three-Component Cross-Electrophile Coupling of 1,3-Dienes with Aldehydes and Aryl Bromides

Ya-Qiong Qi, Shuai Liu, Yan Xu, Yang Li, Tong Su, Hai-Liang Ni, Yuanji Gao, Wenhao Yu, Peng Cao, Ping Hu, Ke-Qing Zhao, Bi-Qin Wang and Bin Chen*

*College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China, Email:

Y.-Q. Qi, S. Liu, Y. Xu, Y. Li, T. Su, H.-L. Ni, Y. Gao, W. Yu, P. Cao, P. Hu, K.-Q. Zhao, B.-Q. Wang, B. Chen, Org. Lett., 2022, 24, 5023-5028.

DOI: 10.1021/acs.orglett.2c01648

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A Ni-catalyzed three-component cross-electrophile coupling of 1,3-dienes with aldehydes and aryl bromides using manganese metal as the reducing agent provides 1,4-disubstituted homoallylic alcohols.

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proposed mechanism

Key Words

homoallylic alcohols, arenes, multicomponent reactions, manganese

ID: J54-Y2022