Deoxytrifluoromethylation of Alcohols

Nicholas E. Intermaggio, Agustin Millet, Dali L. Davis and David W. C. MacMillan*

*Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States, Email: dmacmillprinceton.edu

N. E. Intermaggio, A. Millet, D. L. Davis, D. W. C. MacMillan, J. Am. Chem. Soc., 2022, 144, 11961-11968.

DOI: 10.1021/jacs.2c04807

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Abstract

In situ activation of alcohols by benzoxazolium salts enables a copper metallaphotoredox-mediated direct deoxytrifluoromethylation.

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proposed mechanism

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Key Words

trifluoromethylation, photochemistry

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ID: J48-Y2022