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Nickel-Catalyzed C-S Reductive Cross-Coupling of Alkyl Halides with Arylthiosilanes toward Alkyl Aryl Thioethers

Yu-Zhong Yang, Yang Li, Gui-Fen Lv*, De-Liang He* and Jin-Heng Li*

*Nanchang Hangkong University, Nanchang 330063; Hunan University, Changsha 410082, China, Email:,,

Y.-Z. Yang, Y. Li, G.-F. Lv, D.-L. He, J.-H. Li, Org. Lett., 2022, 24, 5116-5119.

DOI: 10.1021/acs.orglett.2c01954

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A nickel-catalyzed C-S reductive cross-coupling of alkyl halides with arylthiosilanes provides alkyl aryl thioethers. This reaction offers exquisite chemoselectivity, excellent tolerance of diverse functional groups, and wide applications for late-stage modification of biologically relevant molecules.

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proposed mechanism

Key Words

alkylation, aryl sulfides, manganese

ID: J54-Y2022