(NH₄)₂S₂O₈-Mediated Metal-Free Decarboxylative Formylation/Acylation of α-Oxo/Ketoacids and Its Application to the Synthesis of Indole Alkaloids

Votarikari Dinesh and Rajagopal Nagarajan*

*School of Chemistry, University of Hyderabad, Hyderabad 500046, Telangana, India, Email: nagarajanuohyd.ac.in

V. Dinesh, R. Nagarajan, J. Org. Chem., 2022, 87, 10359-10365.

DOI: 10.1021/acs.joc.2c00552

---

see article for more reactions

Abstract

A direct decarboxylative cross-coupling of α-oxo/ketoacids with indoles and β-carbolines in the presence of (NH₄)₂S₂O₈ enables a metal-free formylation/acylation in moderate to good yields under mild reaction conditions.

see article for more examples

proposed mechanism

---

---

Key Words

indoles, ammonium peroxydisulfate

---

ID: J42-Y2022