Organic Chemistry Portal

Abstracts

Search:

Dehydrative Cross-Coupling for C-N Bond Construction under Transition-Metal-Free Conditions

Huicong Xing, Meijuan Chen, Dong Zhang, Zhishuai Geng, Peizhong Xie* and Teck-Peng Loh*

*School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P.R. China, Email: peizhongxienjtech.edu.cn, teckpengntu.edu.sg

H. Xing, M. Chen, D. Zhang, Z. Geng, P. Xie, T.-P. Loh, Org. Lett., 2022, 24, 5657-5662.

DOI: 10.1021/acs.orglett.2c01902


see article for more reactions

Abstract

The combination of Mg2+ and PF6- as counteranion catalyzes a transition-metal-free dehydrative cross-coupling of unactivated primary/secondary alcohols with amines/amides under environmentally benign conditions. A wide range of allylic alcohols and amines/amides were tolerated well in this efficient transformation.


see article for more examples

proposed mechanism

dehydrative cross-coupling of biologically active skeletones



Key Words

allylic amines, sulfonamides


ID: J54-Y2022