Ru-Catalyzed Hydroboration of Ynones Leads to a Nontraditional Mode of Reactivity
Qiang Feng, Shijia Li, Zhiyang Li, Qiaolin Yan, Xiangfeng Lin, Lijuan Song*, Xinhao Zhang*, Yun-Dong Wu* and Jianwei Sun*
*HIT, Shenzhen 518055; PKU Grad School, Shenzhen 518055; Shenzhen Res. Institute, Shenzhen 518057, China,
Email: songlijuan
hit.edu.cn, zhangxhpkusz.edu.cn,
wuydpkusz.edu.cn, sunjwust.hk
Q. Feng, S. Li, Z. Li, Q. Yan, X. Lin, L. Song, X. Zhang, Y.-D. Wu, J. Sun, J. Am. Chem. Soc., 2022, 144, 14846-14855.
DOI: 10.1021/jacs.2c06024
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Abstract
A ruthenium-catalyzed hydroboration of ynones provides vinyl α-hydroxylboronates under mild conditions. This reaction features high efficiency, a broad scope, and complete chemo-, regio-, and stereoselectivity, in spite of many possible competitive pathways.
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proposed reaction pathway
Key Words
allylboronates, α-hydroxyboronates, pinacolborane
ID: J48-Y2022
