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Iron(II)-Catalyzed Nitrene Transfer Reaction of Sulfoxides with N-Acyloxyamides

Tianxing Qi, Ning Fang, Weimin Huang, Jianhui Chen*, Yanshu Luo and Yuanzhi Xia*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email: cjhwzu.edu.cn, xyzwzu.edu.cn

T. Qi, N. Fang, W. Huang, J. Chen, Y. Luo, Y. Xia, Org. Lett., 2022, 24, 5674-5678.

DOI: 10.1021/acs.orglett.2c01990


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Abstract

An iron(II)-catalyzed nitrene transfer reaction of sulfoxides with N-acyloxyamides provides N-acyl sulfoximines with high functional-group compatibility. The transformation was carried out under an air atmosphere at ambient temperature and could be scaled up to gram scale with a low catalyst loading.

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proposed mechanism



Key Words

sulfoximines


ID: J54-Y2022