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Synthesis of Isoxazoles via One-Pot Oxidation/Cyclization Sequence from Propargylamines

Mengyan Duan, Guodong Hou, Yabiao Zhao, Congjun Zhu* and Chuanjun Song*

*Henan University of Technology, Zhengzhou 450001; Zhengzhou University, Zhengzhou 450001, China, Email:,

M. Duan, G. Hou, Y. Zhao, C. Zhu, C. Song, J. Org. Chem., 2022, 87, 11222-11225.

DOI: 10.1021/acs.joc.2c00896

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An oxidation of propargylamines to the corresponding oximes followed by CuCl-mediated intramolecular cyclization provides a series of isoxazoles with a wide range of functional group compatibility.

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proposed mechanism

Key Words

isoxazoles, MCPBA

ID: J42-Y2022