Organic Chemistry Portal



Rongalite-Mediated Transition Metal- and Hydride-Free Chemoselective Reduction of α-Keto Esters and α-Keto Amides

Sivaparwathi Golla and Hari Prasad Kokatla*

*Department of Chemistry, National Institute of Technology Warangal, Warangal, Telangana 506004, India, Email:

S. Golla, H. P. Kokatla, J. Org. Chem., 2022, 87, 9915-9925.

DOI: 10.1021/acs.joc.2c00936

see article for more reactions


The use of inexpensive rongalite as a reducing agent enables a transition metal- and hydride-free chemoselective reduction of α-keto esters and α-keto amides via a radical mechanism to provide a wide range of α-hydroxy esters and α-hydroxy amides in very good yields. This mild and chemoselective method is compatible with other reducible functionalities such as halides, alkenes, amides, and nitriles.

see article for more examples

proposed mechanism

Key Words

reduction of carbonyl compounds, rongalite

ID: J42-Y2022