Visible-Light-Induced Photocatalyst-Free Radical Trifluoromethylation

Yufei Li, Xin Liang, Kaikai Niu, Jun Gu, Fang Liu, Qing Xia*, Qingmin Wang* and Weihua Zhang*

*Nanjing Agricultural University, Nanjing 210095: Nankai University, Tianjin 300071, China, Email: xiaqnjau.edu.cn, wangqmnankai.edu.cn, zhwhnjau.edu.cn

Y. Li, X. Liang, K. Niu, J. Gu, F. Liu, Q. Xia, Q. Wang, W. Zhang, Org. Lett., 2022, 24, 5918-5923.

DOI: 10.1021/acs.orglett.2c02150

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Abstract

The use of trifluoromethyl thianthrenium salts enables high-yielding and scalable trifluoromethylation reactions under visible light irradiation. A free radical homolytic process is involved in this reaction, generating a key trifluoromethyl radical intermediate.

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proposed mechanism

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Key Words

quinoxalinones, photochemistry

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ID: J54-Y2022