Enantioselective Cobalt-Catalyzed Hydroboration of Fluoroalkyl-Substituted Alkenes to Access Chiral Fluoroalkylboronates
Ming Hu, Boon Beng Tan and Shaozhong Ge*
*Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore,
Email: chmgsh
nus.edu.sg
M. Hu, B. B. Tan, S. Ge, J. Am. Chem. Soc., 2022, 144, 15333-15338.
DOI: 10.1021/jacs.2c06488
Abstract
Cobalt complexes generated from Co(acac)2 and bisphosphine ligands catalyze asymmetric hydroboration reactions of fluoroalkyl-substituted terminal alkenes with pinacolborane (HBpin) to afford the corresponding chiral alkylboronates containing fluoroalkyl-substituted stereogenic carbon centers with high enantioselectivity.
see article for more examples
Key Words
benzylic trifluoromethanes, alkylboronates
ID: J48-Y2022
