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Enantioselective Cobalt-Catalyzed Hydroboration of Fluoroalkyl-Substituted Alkenes to Access Chiral Fluoroalkylboronates

Ming Hu, Boon Beng Tan and Shaozhong Ge*

*Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore, Email:

M. Hu, B. B. Tan, S. Ge, J. Am. Chem. Soc., 2022, 144, 15333-15338.

DOI: 10.1021/jacs.2c06488


Cobalt complexes generated from Co(acac)2 and bisphosphine ligands catalyze asymmetric hydroboration reactions of fluoroalkyl-substituted terminal alkenes with pinacolborane (HBpin) to afford the corresponding chiral alkylboronates containing fluoroalkyl-substituted stereogenic carbon centers with high enantioselectivity.

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Key Words

benzylic trifluoromethanes, alkylboronates

ID: J48-Y2022