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Iron-Catalyzed α-Methylation of Ketones Using Methanol as the C1 Source under Photoirradiation

Balakumar Emayavaramban, Priyanka Chakraborty, Pardeep Dahiya and Basker Sundararaju*

*Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India, Email:

B. Emayavaramban, P. Chakraborty, P. Dahiya, B. Sundaraaju, Org. Lett., 2022, 24, 6219-6223.

DOI: 10.1021/acs.orglett.2c02545


Iron catalysis enables a mild, environmentally benign α-methylation of ketones utilizing methanol as the C1 source under visible light irradition. The reaction conditions were favorable for a wide range of ketones with both aromatic and aliphatic backbones.

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proposed mechanism

Key Words

alkylation, photochemistry

ID: J54-Y2022