Iron-Catalyzed α-Methylation of Ketones Using Methanol as the C1 Source under Photoirradiation
Balakumar Emayavaramban, Priyanka Chakraborty, Pardeep Dahiya and Basker Sundararaju*
*Department of Chemistry, Indian Institute of Technology
Kanpur, Kanpur 208016, India, Email: basker
iitk.ac.in
B. Emayavaramban, P. Chakraborty, P. Dahiya, B. Sundaraaju, Org. Lett., 2022, 24, 6219-6223.
DOI: 10.1021/acs.orglett.2c02545
Abstract
Iron catalysis enables a mild, environmentally benign α-methylation of ketones utilizing methanol as the C1 source under visible light irradition. The reaction conditions were favorable for a wide range of ketones with both aromatic and aliphatic backbones.
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proposed mechanism
Key Words
alkylation, photochemistry
ID: J54-Y2022
