Visible-Light-Induced C-F and C-N Bond Cleavage for the Synthesis of gem-Difluoroalkenes
Bin Wang, Cui-Tian Wang, Xue-Song Li, Xue-Yuan Liu* and Yong-Min Liang*
*State Key Laboratory of Applied Organic Chemistry, Lanzhou
University, Lanzhou 730000, China, Email: liuxuey
lzu.edu.cn,
liangymlzu.edu.cn
B. Wang, C.-T. Wang, X.-S. Li, X.-Y. Liu, Y.-M. Liang, Org. Lett., 2022, 24, 6566-6570.
DOI: 10.1021/acs.orglett.2c02528
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Abstract
An efficient photoredox catalytic radical addition/defluoroalkylation coupling reaction between derivatives of primary amines and trifluoromethyl-substituted alkenes provides a series of gem-difluoroalkenes under visible light irradiation. This reaction offers a broad substrate scope and good functional group tolerance.
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proposed mechanism
Key Words
gem-Difluoroalkenes, Allylation, Photochemistry
ID: J54-Y2022
