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A Direct Method for Synthesis of Fluorinated Quinazolinones and Quinoxalines Using Fluorinated Acids without Metals or Additives

Shichen Li, Xueyan Lv, Jianing Ren, Lei Feng, Chen Ma*

*School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. of China, Email:

S. Li, Y. Lv, J. Ren, L. Feng, C. Ma, Synthesis, 2022, 54, 3989-3998.

DOI: 10.1055/a-1824-6352

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The use of trifluoroacetic acid as a CF3 source provides 2-(trifluoromethyl)quinazolin-4-ones and 4-(trifluoromethyl)pyrrolo/indolo[1,2-a]quinoxalines without any catalysts or additives in very good yield.

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Key Words

trifluoromethylation, quinazolinones, quinoxalines, metal-free, solvent-only

ID: J66-Y2022