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Iridium-Catalyzed Branch-Selective and Enantioselective Hydroalkenylation of α-Olefins through C-H Cleavage of Enamides

Xin Sun, En-Ze Lin and Bi-Jie Li*

*Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, China, Email:

X. Sun, E.-Z. Lin, B.-J. Li, J. Am. Chem. Soc., 2022, 144, 17351-17358.

DOI: 10.1021/jacs.2c07477

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An atom-economical iridium-catalyzed asymmetric hydroalkenylation of α-olefins through directed C-H cleavage of enamides is highly branch-selective and enantioselective, delivering trisubstituted alkenes with an allylic stereocenter.

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Key Words


ID: J48-Y2022