Iridium-Catalyzed Branch-Selective and Enantioselective Hydroalkenylation of α-Olefins through C-H Cleavage of Enamides
Xin Sun, En-Ze Lin and Bi-Jie Li*
*Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, China,
Email: bijieli
mail.tsinghua.edu.cn
X. Sun, E.-Z. Lin, B.-J. Li, J. Am. Chem. Soc., 2022, 144, 17351-17358.
DOI: 10.1021/jacs.2c07477
see article for more reactions
Abstract
An atom-economical iridium-catalyzed asymmetric hydroalkenylation of α-olefins through directed C-H cleavage of enamides is highly branch-selective and enantioselective, delivering trisubstituted alkenes with an allylic stereocenter.
see article for more examples
Key Words
ID: J48-Y2022
