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Continuous Flow Microreactor Promoted the Catalytic N-Oxidation Reaction of Pyridine Derivatives

Siyuan Chen, Shanxiu Yang, Hao Wang, Yanning Niu, Zhang Zhang*, Bo Qian*

*Northwest Normal University, Lanzhou, Gansu 730070; Lanzhou Institute of Chemical Physics, Lanzhou 730000, P. R. China, Email:,

S. Chen, S. Yang, H. Wang, Y. Niu, Z. Zhang, B. Qian, Synthesis, 2022, 54, 3999-4004.

DOI: 10.1055/s-0041-1737490

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The use of titanium silicalite (TS-1) in a packed-bed microreactor and H2O2 in methanol as solvent enable the formation of various pyridine N-oxides in very good yields. This flow process is a safer, greener, and more highly efficiency process than using a batch reactor. The device was used for over 800 hours of continuous operation while while the catalyst remained active.

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Key Words

flow chemistry, hydrogen peroxide, N-oxidation, pyridine, green chemistry, titanium silicalite

ID: J66-Y2022