Polyoxometalate-Ionic Liquid-Catalyzed Ritter Reaction for Efficient Synthesis of Amides
Lei Zhang, Bo Chen, Peipei He, Guosong Li, Lan-Cui Zhang*, Shuang Gao*
*Liaoning Normal University, Dalian 116029; Dalian Institute
of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. of China,
Email: zhanglancui
lnnu.edu.cn, sgaodicp.ac.cn
L. Zhang, B. Chen, P. He, G. Li, L.-C. Zhang, S. Gao, Synlett, 2022, 33, 1515-1518.
DOI: 10.1055/a-1854-9958
Abstract
Polyoxometalate-ionic liquid catalysts combine acidity and miscibility. Among them, [BSmim]CuPW12O40 [BSmim = 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium] displayed the highest activity for the Ritter reaction of a variety of alcohols with nitriles, delivering the corresponding amide products in very good yields. Furthermore, the reaction can be easily scaled up to a gram scale.
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Key Words
alcohols, nitriles, amides, Ritter reaction
ID: J72-Y2022
