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Polyoxometalate-Ionic Liquid-Catalyzed Ritter Reaction for Efficient Synthesis of Amides

Lei Zhang, Bo Chen, Peipei He, Guosong Li, Lan-Cui Zhang*, Shuang Gao*

*Liaoning Normal University, Dalian 116029; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. of China, Email:,

L. Zhang, B. Chen, P. He, G. Li, L.-C. Zhang, S. Gao, Synlett, 2022, 33, 1515-1518.

DOI: 10.1055/a-1854-9958


Polyoxometalate-ionic liquid catalysts combine acidity and miscibility. Among them, [BSmim]CuPW12O40 [BSmim = 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium] displayed the highest activity for the Ritter reaction of a variety of alcohols with nitriles, delivering the corresponding amide products in very good yields. Furthermore, the reaction can be easily scaled up to a gram scale.

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Key Words

alcohols, nitriles, amides, Ritter reaction

ID: J72-Y2022