Hypervalent Iodine Reagents Enable C(sp2)-H Amidation of (Hetero)arenes with Iminophenylacetic Acids
Yue Pan, Zhengyi Liu, Peng Zou, Yali Chen and Yiyun Chen*
*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 China, Email: yiyunchensioc.ac.cn
Y. Pan, Z. Liu, P. Zou, Y. Chen, Y. Chen, Org. Lett., 2022, 24, 6681-6685.
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Sulfonamidyl (hetero)arenes can be synthesized by a C(sp2)-H amidation with bench-stable amidyl-iminophenylacetic acids in the presence of a hypervalent iodine reagent. The hypervalent iodine reagent covalently activates the iminophenylacetic acid for the facile sulfonamidyl radical generation under mild photocatalytic oxidative conditions.
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