A Boron-Nitrogen Double Transborylation Strategy for Borane-Catalyzed Hydroboration of Nitriles
Subham Pradhan, Raman Vijaya Sankar and Chidambaram Gunanathan*
*School of Chemical Sciences, National Institute of Science Education and Research (NISER), An OCC of Homi Bhabha National Institute, Bhubaneswar 752050, India,
Email: gunanathan
niser.ac.in
S. Pradhan, R. V. Sankar, C. Gunanathan, J. Org. Chem., 2022, 87, 12386-12396.
DOI: 10.1021/acs.joc.2c01655
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Abstract
The use of 9-BBN dimer as a catalyst and pinacolborane as a turnover reagent enables an efficient hydroboration of nitriles to provide N,N-diborylamines, which act as efficient synthons for the synthesis of primary amines and secondary amides.
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proposed mechanism
Key Words
reduction of nitriles, pinacolborane
ID: J42-Y2022
