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Amine-Free O-Sulfonylation by a Combination of 4-Methylpyridine N-Oxide Catalyst with 4 Molecular Sieves

Keisuke Yoshida*, Yuma Matsumoto, Juo Masuda, Shinji Kitagaki

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan, Email: kyoshidameijo-u.ac.jp

K. Yoshida, Y. Matsumoto, J. Masuda, S. Kitagaki, Synlett, 2022, 33, 1570-1574.

DOI: 10.1055/a-1865-2970


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Abstract

4-Methylpyridine N-oxide catalyzes an amine-free sulfonylation of various alcohols in the presence of 4 molecular sieves at room temperature. This mild method gives various sulfonylated products in high yields, and can be applied to base-sensitive substrates.

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Key Words

sulfonylation, methylpyridine oxide, alcohols, molecular sieves, sulfonates, mesylation


ID: J72-Y2022