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Langlois Reagent Mediated Tandem Cyclization of o-Hydroxyaryl Enaminones for the Synthesis of 3-(Trifluoromethyl)chromones

Pradeepkumar Thota, Kalidasu Sheelam, Shrinivas Kottawar, K. Shivakumar, Muralidharan Kaliyaperumal, Satyanarayana Yennam, Manoranjan Behera*

*Chemistry Services, Aragen Life Sciences, Survey Nos: 125 (part) and 126, IDA Mallapur, Hyderabad-500076, Telangana, India, Email:

P. Thota, K. Sheelam, S. Kottawar, K. Shivakumar, M. Kaliyaperumal, S. Yennam, M. Behera, Synlett, 2022, 33, 1660-1664.

DOI: 10.1055/a-1906-3382

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The use of the Langlois reagent enables an efficient and regioselective synthesis of various 3-(trifluoromethyl)chromones from enamino ketones. This convenient procedure offers high product purity and yield.

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Key Words

trifluoromethylation, Langlois reagent, tert-butyl hydroperoxide, enamino ketones, chromones, copper acetate

ID: J72-Y2022