Construction of C(sp²)-Si Bonds via Ligand-Promoted C-C Bonds Cleavage of Unstrained Ketones

Xing Wang, Zhen-Yu Wang, Xu Zhang, Hui Xu and Hui-Xiong Dai*

*State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China, Email: hxdaisimm.ac.cn

X. Wang, Z.-Y. Wang, X. Zhang, H. Xu, H.-X. Dai, Org. Lett., 2022, 24, 7344-7349.

DOI: 10.1021/acs.orglett.2c02841

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Abstract

An efficient palladium-catalyzed silylation of activated aryl and alkenyl ketones offers high efficiency and broad substrate scope. Further applications in the late-stage diversification of biologically important molecules demonstrate the synthetic utility of this method.

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proposed mechanism

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Key Words

arylsilanes

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ID: J54-Y2022