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B2pin2-Mediated Cascade Cyclization/Aromatization Reaction: Facial Access to Functionalized Indolizines

Xiaoning Li, Zunsheng Chen, Weiming Chen, Xin Xie, Hui Zhou, Yingmei Liao, Fuchao Yu* and Jiuzhong Huang*

*Kunming University of Science and Technology, Kunming 650500; Gannan Medical University, Ganzhou 341000, PR China, Email: yufckust.edu.cn, huangjzgmu.edu.cn

W.-W. Ding, Y. Zhou, S. Song, Z.-Y. Han, Org. Lett., 2022, 24, 7350-7354.

DOI: 10.1021/acs.orglett.2c02905



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Abstract

B2pin2 mediates a radical cascade cyclization/aromatization reaction of enaminone with pyridine to provide valuable functionalized indolizines under metal-, external oxidant-, and base-free conditions. The reaction is compatible with a broad range of functional groups, such as halogens, π-systems, and heterocycles.

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proposed mechanism



Key Words

indolizines, bis(pinacolato)diboron


ID: J54-Y2022