Palladium-Catalyzed Thiocarbonylation of Aryl Iodides with S-Aryl Thioformates via Thioester Transfer

Ruiting Yang, Qiumin Xie, Qian Yan, Xiuli Zhang* and Bao Gao*

*School of Science, Anhui Agricultural University, Hefei, 230036, P. R. China, Email: zhxiuli163.com, bgao0221ahau.edu.cn

R. Yang, Q. Xie, Q. Yan, X. Zhang, B. Gao, Org. Lett., 2022, 24, 7555-7559.

DOI: 10.1021/acs.orglett.2c02953

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Abstract

A palladium-catalyzed reaction of aryl iodides with S-aryl thioformates as thioester sources proceeded at ambient temperature. A variety of substrates furnishes thioesters in good yields under the reaction conditions. A gram-scale reaction was also conducted, indicating that large-scale synthesis of thioesters may be viable using this method.

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proposed mechanism

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Key Words

arylation

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ID: J54-Y2022