Switchable Reductive N-Trifluoroethylation and N-Trifluoroacetylation of Indoles with Trifluoroacetic Acid and Trimethylamine Borane
Yao-Fu Zeng, Ming-Xi Zhou, Yi-Na Li, Xin Wu, Yu Guo* and Zhen Wang*
*Hengyang Medical School, University of South China,
Hengyang, Hunan 421001, China, Email: guoyuhy
126.com, zhenwlzu.edu.cn
Y.-F. Zeng, M.-X. Zhou, Y.-N. Li, X. Wu, Y. Guo, Z. Wang, Org. Lett., 2022, 24, 7440-7445.
DOI: 10.1021/acs.orglett.2c03011
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Abstract
Metal-free reductive N-trifluoroethylation and N-trifluoroacetylation of indoles provide trifluoroethylated or trifluoroacetylated indolines depending on the loading of trimethylamine borane as reducing agent and TFA as trifluoroethyl or trifluoroacetyl source, respectively.
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Key Words
indolines, trimethylamine borane
ID: J54-Y2022
