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A Facile and Efficient One-Pot Procedure for the Synthesis of Novel 2-Substituted 3-Thioxoisoindolin-1-one Derivatives

Fatemeh Gholami, Ali Moazzam, Saeed Bahadorikhalili, Mehdi Adib*, Samanesadat Hosseini, Bagher Larijani, Mohammad Mahdavi*

*School of Chemistry, College of Science, University of Tehran, Tehran; Tehran University of Medical Sciences, Tehran 11174, Iran Email:,

F. Gholami, A. Moazzam, S. Bahadorikhalili, M. Adib, S. Hosseini, B. Larijani, M. Mahdavi, Synlett, 2022, 33, 1729-1732.

DOI: 10.1055/a-1912-2293

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An efficient synthesis of 2-substituted 3-thioxoisoindolin-1-one derivatives is based on the solvent-free reaction of 2-carboxybenzaldehyde with aliphatic amines and sulfur at 100C. This reaction enables a facile synthesis of asymmetric thioxoisoindolin-1-one derivatives with phthalimide backbones.

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Key Words

benzo-fused N-heterocycles, phthalimides, multicomponent reactions

ID: J72-Y2022