Potassium Alkoxide as an Efficient Catalyst for Nucleophilic Perfluoroalkylation: Attempt at Anion-Controlled Enantioselective Insertion of a Trifluoromethyl Group
Taiga Yurino*, Hiroyuki Yamashita, Yuanrong Shan, Zhen Wu, Takeshi Ohkuma*
*Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Sapporo, Hokkaido 060-8628, Japan,
Email: tyurino
eng.hokudai.ac.jp, ohkumaeng.hokudai.ac.jp
T. Yurino, H. Yamashita, Y. Shan, Z. Wu, T. Ohkuma, Synlett, 2022, 33, 1739-1744.
DOI: 10.1055/a-1914-1518
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Abstract
Potassium alkoxide is a highly active catalyst for the nucleophilic trifluoromethylation of both aldehydes and ketones, affording the corresponding trifluoromethylated products in high yields at low catalyst loadings.
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Key Words
ID: J72-Y2022
