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Mechanochemical Asymmetric Transfer Hydrogenation of Diketones to Access Chiral 1,3-Diols under Solvent-Free Conditions

Chengyi Wang, Shaomin Deng, Rui Chen, Guohua Liu, Tanyu Cheng*, Rui Liu* 

*Shanghai Normal University, Shanghai, P. R. of China, Email:,

C. Wang, S. Deng, R. Chen, G. Liu, T. Cheng, R. Liu, Synlett, 2022, 33, 1858-1862.

DOI: 10.1055/a-1906-3304


A mechanochemical asymmetric transfer hydrogenation (ATH) of diketones in the presence of a ruthenium complex under solvent-free conditions provides chiral 1,3-diol derivatives. This protocol benefits from rapid reaction kinetics, no use of solvents, and excellent enantioselectivity. In addition, this reaction can easily be performed on a gram scale.

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Key Words

asymmetric catalysis, formic acid, transfer hydrogenation, reduction of carbonyl compounds, diols, ruthenium catalysis, solvent-free reaction, mechanochemistry

ID: J72-Y2022