Mechanochemical Asymmetric Transfer Hydrogenation of Diketones to Access Chiral 1,3-Diols under Solvent-Free Conditions
Chengyi Wang, Shaomin Deng, Rui Chen, Guohua Liu, Tanyu Cheng*, Rui Liu*
*Shanghai Normal University, Shanghai, P. R. of China,
Email: tycheng
shnu.edu.cn, rliushnu.edu.cn
C. Wang, S. Deng, R. Chen, G. Liu, T. Cheng, R. Liu, Synlett, 2022, 33, 1858-1862.
DOI: 10.1055/a-1906-3304
Abstract
A mechanochemical asymmetric transfer hydrogenation (ATH) of diketones in the presence of a ruthenium complex under solvent-free conditions provides chiral 1,3-diol derivatives. This protocol benefits from rapid reaction kinetics, no use of solvents, and excellent enantioselectivity. In addition, this reaction can easily be performed on a gram scale.
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Key Words
asymmetric catalysis, formic acid, transfer hydrogenation, reduction of carbonyl compounds, diols, ruthenium catalysis, solvent-free reaction, mechanochemistry
ID: J72-Y2022
