Mechanochemical Asymmetric Transfer Hydrogenation of Diketones to Access Chiral 1,3-Diols under Solvent-Free Conditions
Chengyi Wang, Shaomin Deng, Rui Chen, Guohua Liu, Tanyu Cheng*, Rui Liu*
*Shanghai Normal University, Shanghai, P. R. of China, Email: tychengshnu.edu.cn, rliushnu.edu.cn
C. Wang, S. Deng, R. Chen, G. Liu, T. Cheng, R. Liu, Synlett, 2022, 33, 1858-1862.
A mechanochemical asymmetric transfer hydrogenation (ATH) of diketones in the presence of a ruthenium complex under solvent-free conditions provides chiral 1,3-diol derivatives. This protocol benefits from rapid reaction kinetics, no use of solvents, and excellent enantioselectivity. In addition, this reaction can easily be performed on a gram scale.
see article for more examples