Organic Chemistry Portal

Abstracts

Search:

Photoelectrochemical Asymmetric Catalysis Enables Direct and Enantioselective Decarboxylative Cyanation

Xiao-Li Lai, Ming Chen, Yuqi Wang, Jinshuai Song* and Hai-Chao Xu*

*Zhengzhou University, Zhengzhou, Henan 450001; Xiamen University, Xiamen 361005, PR China, Email: jssongzzu.edu.cn, haichao.xuxmu.edu.cn

X.-L. Lai, M. Chen, Y. Wang, J. Song, H.-C. Xu, J. Am. Chem. Soc., 2022, 144, 20201-20206.

DOI: 10.1021/jacs.2c09050


Abstract

A photoelectrochemical reaction converts carboxylic acids to enantioenriched nitriles by employing cerium/copper relay catalysis with a cerium salt for catalytic decarboxylation and a chiral copper complex for stereoselective C-CN formation.


see article for more examples


proposed mechanism



Key Words

nitriles, electrochemistry, photochemistry


ID: J48-Y2022