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Transition-Metal-Free Synthesis of 3-Acyl Chromones by the Tandem Reaction of Ynones and Methyl Salicylates

Ya-Fang Ye, Feng Li, Jia-Le Chen, Zi-Qian An, Gui-Ying Zhang and Yan-Bo Wang*

*College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China, Email:

Y.-F. Ye, F. Li, J.-L. Chen, Z.-Q. An, G.-Y. Zhang, Y.-B. Wang, J. Org. Chem., 2022, 87, 14005-14015.

DOI: 10.1021/acs.joc.2c01637


A facile and effective tandem reaction of ynones and methyl salicylates provides a broad range of 3-acyl chromones in good yields. This protocol offers easily accessible substrates, broad substrate scope, and high regioselectivity under mild and transition-metal-free conditions.

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proposed mechanism

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ID: J42-Y2022