Metal-Free Syntheses of α-Ketothioamide and α-Ketoamide Derivatives from Sulfoxonium Ylides
Trayambek Nath Chaubey, Paran J. Borpatra, Ajay Sharma and Satyendra Kumar Pandey*
*Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India, Email: skpandey.chembhu.ac.in
T. N. Chaubey, P. J. Borpatra, A. Sharma, S. K. Pandey, Org. Lett., 2022, 24, 8062-8066.
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The reaction of sulfoxonium ylides with primary or secondary amines afforded α-ketothioamides in the presence of elemental sulfur, whereas α-ketoamides were produced when I2 and TBHP were present. This simple, scalable reaction proceeded well at room temperature, tolerated a range of functional group, and generated the corresponding products in very good yields.
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