Switchable Synthesis of 2-Methylene-3-aminoindolines and 2-Methyl-3-aminoindoles Using Calcium Carbide as a Solid Alkyne Source
Zhiqiang Wang, Zeshuai Zhang and Zheng Li*
*College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China,
Email: lizheng
nwnu.edu.cn
Z. Wang, Z. Zhang, Z. Li, Org. Lett., 2022, 24, 8067-8071.
DOI: 10.1021/acs.orglett.2c03406
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Abstract
The one-pot reaction of N-(2-formylaryl)sulfonamides, secondary amines, and calcium carbide as convenient alkyne source enables a switchable synthesis of 2-methylene-3-aminoindolines and 2-methyl-3-aminoindoles in good yields.
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proposed mechanism
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Key Words
indolines, indoles, multicomponent reactions
ID: J54-Y2022
