Organic Chemistry Portal



Switchable Synthesis of 2-Methylene-3-aminoindolines and 2-Methyl-3-aminoindoles Using Calcium Carbide as a Solid Alkyne Source

Zhiqiang Wang, Zeshuai Zhang and Zheng Li*

*College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China, Email:

Z. Wang, Z. Zhang, Z. Li, Org. Lett., 2022, 24, 8067-8071.

DOI: 10.1021/acs.orglett.2c03406

see article for more reactions


The one-pot reaction of N-(2-formylaryl)sulfonamides, secondary amines, and calcium carbide as convenient alkyne source enables a switchable synthesis of 2-methylene-3-aminoindolines and 2-methyl-3-aminoindoles in good yields.

see article for more examples

proposed mechanism

Key Words

indolines, indoles, multicomponent reactions

ID: J54-Y2022