Base-Promoted (3 + 2) Cycloaddition of Trifluoroacetohydrazonoyl Chlorides with Imidates En Route to Trifluoromethyl-1,2,4-Triazoles
Yue Zhang, Jun-Liang Zeng, Zhen Chen* and Ren Wang*
*Nanjing Forestry University, Nanjing 210037, Jiangsu; Institute of Botany, Jiangsu Province
and CAS, Nanjing 210014, China,
Email: chenzhen1719
njfu.edu.cn, rwangcnbg.net
Y. Zhang, J.-L. Zeng, Z. Chen, R. Wang, J. Org. Chem., 2022, 87, 14514-14522.
DOI: 10.1021/acs.joc.2c01926
Abstract
A base-mediated (3 + 2) cycloaddition of trifluoroacetohydrazonoyl chlorides with imidates provides 3-trifluoromethyl-1,2,4-triazoles. This convenient reaction offers good yields, a broad substrate scope, and excellent regioselectivity.
see article for more examples
Key Words
ID: J42-Y2022
