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Base-Promoted (3 + 2) Cycloaddition of Trifluoroacetohydrazonoyl Chlorides with Imidates En Route to Trifluoromethyl-1,2,4-Triazoles

Yue Zhang, Jun-Liang Zeng, Zhen Chen* and Ren Wang*

*Nanjing Forestry University, Nanjing 210037, Jiangsu; Institute of Botany, Jiangsu Province and CAS, Nanjing 210014, China, Email:,

Y. Zhang, J.-L. Zeng, Z. Chen, R. Wang, J. Org. Chem., 2022, 87, 14514-14522.

DOI: 10.1021/acs.joc.2c01926


A base-mediated (3 + 2) cycloaddition of trifluoroacetohydrazonoyl chlorides with imidates provides 3-trifluoromethyl-1,2,4-triazoles. This convenient reaction offers good yields, a broad substrate scope, and excellent regioselectivity.

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Key Words


ID: J42-Y2022